Penelitian Noni Tahun 1996-2000

Strang International Cancer Prevention Conference, Poster Session, Nov. 10-11, 2000
Cancer Prevent Effect of Morinda Citrifolia
Wang, M-Y

In an in-vivo study, TAHITIAN NONI Juice reduced DNA adducts caused by 7,12-dimethylbenz (?)-anthracene (DMBA). TNJ showed stronger antioxidant activities compared to Vitamin C, Pycnogenol?, and Grape seed powder. The antioxidant activities of TNJ may contribute to the mechanism of reducing DNA adduct formation.

Journal Natural Products, 63(8):1182-1183, 2000
Novel Glycosides from Noni (Morinda citrifolia)
Wang, M., Kikuzaki, H., Jin, Y., Nakatani, N., Zhu, N., Csiszar, K., Boyd, C., Rosen, R.T., Ho, C.T.

Three new glycosides were isolated from Morinda citrifolia (noni) fruit. They are 6-O- (beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-glucopyranose, 6-O- (beta-D-glucopyranosyl)-1-O-hexanoyl-beta-D-glucopyranose and 3-methylbut-3-enyl 6-O-beta-D-glucopyranosyl-beta-D-glucopyranoside.

American Journal of Kidney Diseases, 35(2):310-312, 2000
Noni Juice (Morinda Citrifolia): Hidden Potential for Hyperkalemia?
Mieller, B., Scott, M.K., Sowinski, K.D., Prag, K.A.

Report of a patient with chronic renal insufficiency who self-medicated with an alternative medicine, noni juice (Morinda Citrifolia). The patient had hyperkalemia. The potassium concentration in noni juice was determined and found to be 56.3 mEq/l, similar to that in orange juice and tomato juice.

J. Trop. Forest Prod., 5:32-38, 1999
Malaysian Tropical Forest Medicinal Plants: A Source of Natural Antioxidants
Vimala, S., Adenan, M.I.

A total of 70 samples of different plant parts from 45 species of Malaysian tropical forest medicinal plants was screened for antioxidant (free radical scavenging) activity against autoxidation (oxidation by direct combination with oxygen (such as air) at ordinary temperatures) of linoleic acid (an essential fatty acid which cannot be made in the body) in a water-alcohol system. The crude extracts were assayed, and some were found to exhibit potent antioxidant activity relative to a synthetic antioxidant. A total of 59 samples from 43 species exhibited high antioxidant activity (more than 90%), 9 showed moderate activity (50 to 90%) while 2 exhibited low activity (less than 50%). The antioxidant activity observed in this study indicates that many of the local tropical medicinal plants possess free radical scavenging compounds that form a natural defense mechanism against activated oxygen damage (free radical mediated damage in stress situations) in plants.

Phytotherapy Research, 13:380-387, 1999
An Immunomodulatory Polysaccharide-Rich Substance from the Fruit Juice of Morinda citrifolia (Noni) with Antitumour Activity
Hirazumi, A., Furusawa, E.

The fruit juice of Morinda citrifolia (noni) contains a polysaccharide-rich substance (noni-ppt) with anti-tumor activity. Therapeutic administration of noni-ppt significantly increased survival time of tumor bearing mice. Results also suggested the possibility that noni-ppt may suppress tumor growth through activation of the host immune system. Noni-ppt was also capable of stimulating the release of several cytokines from immune cells. Improved survival time and curative effects occurred when noni-ppt was combined with sub-optimal doses of standard chemotherapeutic agents, suggesting important clinical applications of noni-ppt as a supplemental agent in cancer treatment.

Federation of European Biochemical Societies Letters, 12(2-3):173-176, 1999
Stimulation of Ultraviolet-induced Apoptosis of Human Fibroblast UVr-1 Cells by Tyrosine Kinase Inhibitors.
Hiwasa, T., Arase, Y., Chen, Z., Kita, K., Umeza, Zawa, K., Ito, H., Suzuki, N.

Damnacanthal, from Morinda citrifolia exhibited apoptosis (cell death) in cancer cells. Damnacanthal treated cancer cells showed more DNA fragmentation from ultraviolet irradiation, than cancer cells treated with ultraviolet radiation alone.

Journal Agricultural Food Chemistry, 47:(12):4880-4882, 1999
Novel Trisaccharide Fatty Acid Ester Identified from the Fruits of Morinda citrifolia (Noni).
Wang, M., Kikuzaki, H., Csiszar, K., Boyd, C.D., Maunakea, A., Fong, S.F., Ghai, G., Rosen, R.T., Nakatani, N., Ho, C.T.

Two known glycosides and a novel trisaccharide fatty acid ester were isolated from Morinda citrifolia (noni) fruit. The novel trisaccharide fatty acid ester was 2,6-di-O- (beta-D-glucopyranosyl)-1-O-octanoyl-beta-D-glucopyranose. The known compounds were rutin and asperulosidic acid.

Journal of Ethnopharmacology, 63(3):201-208, 1998
Jamu Gendong, A Kind of Traditional Medicine in Indonesia: The Microbial Contamination of its Raw Materials and End Products.
Limyati, D.A., Juniar, B.L.

Microbial contamination of seven kinds of Jamu Gendong (JG) and their raw materials was conducted. The results showed the samples were heavily contaminated with bacteria, yeast and molds. Similar results were obtained from the plant material constituents of JG. Morinda citrifolia fruit was less contaminated and can be screened for antibacterial and antifungal activities.

Doctor of Philosophy Dissertation, University of Hawaii, Biomedical Sciences (Pharmacology), Dec. 1997
Antitumor Studies of a Traditional Hawaiian Medicinal Plant, Morinda citrifolia (Noni), In Vitro and In Vivo
Hirazumi, A.Y.

The fruit juice of Morinda citrifolia L. (Noni) contains a polysaccharide-rich precipitate (noni-ppt) with antitumor activity in the Lewis Lung (LLC) peritoneal carcinomatosis model. Noni-ppt was capable of stimulating the release of several mediators from murine effector cells. The pattern of release of these mediators suggested that noni-ppt may promote both a non-specific and Th1 cell mediated antitumor response. Therapeutic administration of noni-ppt demonstrated significant suppression of S.180 ascites growth in allogenic animals, without being substantially cytotoxic to these cells in vitro. Improved survival time and curative effects occurred when noni-ppt was combined with sub-optimal doses of the standard chemotherapeutic agents.