Penelitian Noni Tahun 1991-1995

Journal of Ethnopharmacology, 49:23-32, 1995
Anti-Microbial Activity and Anti-Complement Activity of Extracts Obtained from Selected Hawaiian Medicinal Plants
Lochner, C.P., Burch, M.T., Mower, H.F., Berestecky, J., Davis, H., Van Poel, B., Lasure, A., Vanden Berghe, D.A., Vlietinck, A.J.

Selected plants (including Morinda citrifolia) having a history of use in Polynesian traditional medicine for the treatments of infectious disease were investigated for anti-viral, anti-fungal, and anti-bacterial activity in vitro. Several extraction techniques are explained.

Proceedings of the Western Pharmacology Society, 37:145-146, 1994
Anticancer Activity of Morinda citrifolia (Noni) on Intraperitoneally Implanted Lewis Lung Carcinoma in Syngeneic Mice
Hirazumi, A., Furusawa, E., Chou, S.C., Hokama, Y.

Morinda citrifolia (noni) juice was shown to have antitumor activity on Lewis Lung carcinoma in mice. The ethanol precipitate (noni-ppt) was not directly toxic to cancer cells. Instead, it acts indirectly by enhancing the host immune system involving macrophages or lymphocytes. Noni-ppt had a beneficial effect when combined with sub-optimal doses of chemotherapeutic agents. This suggests a possibility of clinical application of noni-ppt in cancer treatment.

Master of Science Thesis for Biochemistry, Univ. Hawaii, Dec. 1993
The Isolation and Characterization of a Fluorescent Compound from the Fruit of Morinda citrifolia (Noni): Studies On The 5-Ht Receptor System
Sim, H.H.

The isolation and characterization of scopoletin from the fruit of Morinda citrifolia (noni) is presented.

J. Agric. Food Chem., 52(19):5843-5848, 2004
Chemical constituents of Morinda citrifolia fruits inhibit copper-induced low-density lipoprotein oxidation
K. Kamiya, Tanaka, Y., Endang, H., Umar, M., Satake, T.

Extracts of the fruits of Morinda citrifolia inhibited arteriosclerosis (thickening and hardening of the arteries) by 88% and 96%. Two novel compounds (americanoic acid A and morindolin) were also isolated. Four other compounds were found to exhibit strong anti-oxidant (scavenging of free radicals) activity. The activity of these compounds is mainly due to their number of phenolic hydroxyl groups (weakly acidic organic compounds, containing one or more atoms of hydrogen and oxygen bonded together).

J. Medicinal Food, 7:343-348, 2004
The Evaluation of Nitric Oxide Scavenging Activity of Certain Indian Medicinal Plants In Vitro: A Preliminary Study
Jagetia, G.S., Baliga, M.S.

In this in-vitro study, the authors evaluated the nitric oxide (NO) scavenging activity of 17 commonly used Indian medicinal plants. Most of the plant extracts tested demonstrated direct scavenging of NO and exhibited significant activity. In terms of potency of scavenging activity, Morinda citrifolia (Noni) ranked 3rd among the 17 plants tested. The authors conclude that these medicinal plants might be potent and novel therapeutic agents for scavenging of NO and the regulation of pathological conditions caused by excessive generation of NO and its oxidation product, peroxynitrite.

Cancer Letters, 73:161-166, 1993
Induction of Normal Phenotypes in ras-transformed Cells by Damnacanthal from Morinda citrifolia
Hiramatsu, T., Imoto, M., Koyano, T., Umezawa, K.

An anthraquinone, damnacanthal, was isolated from the chloroform extract of the root of Morinda citrifolia. Damnacanthal induced normal morphology and cytoskeletal structure modification in ras-transformed cancer cells. Thus damnacanthal is a new inhibitor of ras function (which is responsible for these cells becoming cancerous).

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